The Neurodevelopmental Hypothesis of Schizophrenia
نویسندگان
چکیده
منابع مشابه
Neurodevelopmental hypothesis of schizophrenia
The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be...
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While multiple theories have been put forth regarding the origin of schizophrenia, by far the vast majority of evidence points to the neurodevelopmental model in which developmental insults as early as late first or early second trimester lead to the activation of pathologic neural circuits during adolescence or young adulthood leading to the emergence of positive or negative symptoms. In this ...
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The original neurodevelopmental hypothesis of schizophrenia presented by D.R. Weinberger in 1987 focused on pathogenesis and did not address etiology. Available evidence indicates that genetic factors are the principal cause of schizophrenia. It is imperative that any pathogenetic model for schizophrenia takes into account what is now known about genetic mechanisms of illness. Recent advances i...
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A series of studies has shown that neonatal excitotoxic disconnection of the rat ventral hippocampus may serve as a heuristic model of schizophrenia. The model mimics a spectrum of neurobiologic and behavioural features of schizophrenia. It produces functional pathology in critical brain regions implicated in schizophrenia and connected with the hippocampal formation, namely, the striatum, nucl...
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1017 " Identifying ways to conduct neuro-imaging with a population that is unable to respond to requests to 'lie still' is an important advance. " In the study reported in this issue, Gilmore et al. (1) demonstrated that neuroimaging the brain in infants at risk for schizophrenia is feasible. This work may lead to advances in understanding the neurobiological underpinnings of the neurodevelopme...
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ژورنال
عنوان ژورنال: Psychiatric Clinics of North America
سال: 2012
ISSN: 0193-953X
DOI: 10.1016/j.psc.2012.06.002